[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone, also known as **SB-203580**, is a **potent and selective inhibitor of p38 mitogen-activated protein kinase (MAPK)**.

Here's why it's important for research:

**1. Understanding the Role of p38 MAPK:**

* p38 MAPK is a crucial signaling molecule involved in various cellular processes, including inflammation, apoptosis, and stress responses.
* Inhibiting p38 MAPK has therapeutic potential for treating inflammatory diseases, pain, and other conditions.

**2. Investigating p38 MAPK-Related Diseases:**

* SB-203580 is a valuable tool for researchers studying the role of p38 MAPK in:
* **Inflammation:** Rheumatoid arthritis, inflammatory bowel disease, sepsis
* **Pain:** Neuropathic pain, inflammatory pain
* **Neurological disorders:** Alzheimer's disease, Parkinson's disease
* **Cancer:** Tumor growth, metastasis

**3. Drug Development:**

* SB-203580 has been investigated as a potential drug candidate for various diseases.
* Although it hasn't reached clinical approval, its selective inhibition of p38 MAPK provides valuable insights for developing new therapies.

**4. Research Applications:**

* SB-203580 is used in cell culture experiments to:
* Study the downstream effects of p38 MAPK inhibition
* Identify new targets for p38 MAPK-related diseases
* Evaluate the efficacy of new drug candidates

**5. Chemical Properties:**

* SB-203580 is a synthetic compound with a molecular weight of 361.4 g/mol.
* It is a crystalline solid and has high affinity for p38 MAPK.

**In summary, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone (SB-203580) is a critical research tool for understanding the role of p38 MAPK in various diseases and for developing new therapeutic agents.**